By L. Robert, T. Fulop, T. Fulop
Getting older encouraged a number of theories attempting to rationalize the getting older approach universal to all dwelling beings. during this e-book an important environmental and intrinsic mechanisms all for the getting older strategy and in its pathological results are reviewed. moreover theoretical and experimental facts of crucial theoretical parts according to Darwinian evolution, mobile getting older, function of phone membranes, unfastened radicals and oxidative strategies, receptor-mediated reactions, the extracellular matrix and immune features in addition to an important environmental and intrinsic mechanisms concerned about the getting older method and in its pathological outcomes are mentioned. those displays of theories and comparable experimental evidence supply a world evaluation of latest options of the biology of the getting older procedure and are of crucial examining not just for experts during this box but additionally for practitioners of medical, clinical, social and experimental sciences.
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Additional resources for Aging: Facts and Theories
Some of the distinctions between the ﬁbroblasts from different tissues are probably necessary to provide for the metabolism of the respective organs and create the appropriate microenvironment. The need for the interaction between ﬁbroblasts and other cell types during development is well known. Mouse embryo mammary rudiments fail to develop in the absence of mesenchyme; the instructive effect of mesenchyme on branching is speciﬁc since embryonic mammary epithelium exposed to salivary gland mesenchyme assumes a salivary-like branching .
2 Macieira-Coelho A, Pontén J, Philipson L: The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro. Exp Cell Res 1966; 42:673–684. 3 Macieira-Coelho A, Berumen L: The cell cycle during growth inhibition of human embryonic ﬁbroblasts in vitro. Proc Soc Exp Biol Med 1973;144: 43–47. 4 Macieira-Coelho A: Are non-dividing cells present in ageing cell cultures? Nature 1974;248: 421–422. 5 Absher PM, Absher RG: Clonal variation and aging of diploid ﬁbroblasts.
Since it was thought that aging favors malignant transformation, speculations were made to ﬁnd a relationship between ‘cell senescence’ and cancers, which led to several paradoxes. The contradictions and paradoxes should be cleared to reestablish logic and order in the ﬁeld and understand its relevance for human aging. © 2014 S. Karger AG, Basel The Concept of Aging of Proliferative Cells The study of aging of proliferative cells was initiated by the work of Hayﬂick and Moorhead  who proposed that the loss of the division potential of human ﬁbroblasts through proliferation in vitro is an expression of aging at the cellular level.