Download Aging and Age Related Ocular Diseases (Ophthalmologica, 1) by E. Lütjen-Drecoll PDF

By E. Lütjen-Drecoll

The phenomenon of getting older is characterised via quite a few degenerative alterations, which differentially have an effect on the hugely really good buildings in the eye, akin to the in basic terms mobile lens, the brain-derived retina and the connective tissue of the uvea and sclera. hence, the attention can function a good version procedure to review age-related degenerative ailments. an outline article bargains with the molecular biology of alpha-B-crystallin, and unique articles supply extra perception into the distribution and attainable sensible importance of nonlenticular alpha-B-crystallin. Retinal transplantation reviews which may finally result in treatment for tapetoretinal degeneration and age-related macular degeneration are mentioned. extra, elements that impact the advance of the retinal tissues are investigated. And one other review examines cells of the deep lens fibers. This detailed factor is an in-depth resource of data to ophthalmologists in examine and perform.

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In conclusion, it is possible to say that substances that contract trabecular meshwork strips reduce outflow in the model of the perfused anterior segment, while substances that relax trabecular meshwork induce an increase in the outflow rate. Ophthalmologica 2000;214:33–53 39 Fig. 8. Measurement of intracellular calcium using the fura method. Endothelin increased cytosolic calcium concentration in human trabecular meshwork cells. Intracellular Calcium It is a well-established fact that smooth-muscle contractility is regulated by the concentration of intracellular calcium [35, 99, 100].

Physiologically, the regulation of two such massively different parameters as accommodation and intraocular pressure by the tone of the same muscle seems surprising. Copyright © 2000 S. Karger AG, Basel ABC © 2000 S. com/journals/oph Dr. Friederike Stumpff Institut für Klinische Physiologie, Freie Universität Berlin Hindenburgdamm 30 D–12200 Berlin (Germany) Tel. de Work done during the last decade has established that, in addition to being passively distended by the ciliary muscle, the trabecular meshwork has contractile properties of its own [1], and that the contraction and relaxation of this structure may influence ocular outflow in the sense that relaxation reduces intraocular pressure.

The response to endothelin seems to follow a mechanism similar to that of other receptor-mediated signalling cascades. In summary, it appears that agents that contract trabecular meshwork depolarize trabecular meshwork cells. This corresponds to the classical, well-described mechanism known for other preparations of smooth-muscle tissue. However, it must be pointed out that contractility experiments using high-potassium solution imply that only part of the contractile response of trabecular meshwork is mediated by changes in membrane potential [29], an important part apparently being due to non-voltagemediated, pharmacomechanical coupling [36, 133].

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